Technology Process of 1-Benzyl-6-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-3-(4-methoxy-3-methyl-benzyl)-piperazine-2,5-dione
There total 8 articles about 1-Benzyl-6-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-3-(4-methoxy-3-methyl-benzyl)-piperazine-2,5-dione which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrazine hydrate;
In
N,N-dimethyl-formamide;
for 1h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 10percent aq. KOH / methanol / 2.5 h / Ambient temperature
2: 56 percent / CF3COOH / 4 h / Heating
3: 88 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 1 h
4: 78 percent / t-BuOK / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature
5: 100 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) r.t., 2 h
6: 83 percent / NH2NH2*H2O / dimethylformamide / 1 h / Ambient temperature
With
potassium hydroxide; potassium tert-butylate; sodium hydride; hydrazine hydrate; trifluoroacetic acid;
In
methanol; N,N-dimethyl-formamide; tert-butyl alcohol;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 56 percent / CF3COOH / 4 h / Heating
2: 88 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 1 h
3: 78 percent / t-BuOK / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature
4: 100 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) r.t., 2 h
5: 83 percent / NH2NH2*H2O / dimethylformamide / 1 h / Ambient temperature
With
potassium tert-butylate; sodium hydride; hydrazine hydrate; trifluoroacetic acid;
In
N,N-dimethyl-formamide; tert-butyl alcohol;