4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester

Base Information

Chemical Name:4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester
CAS No.:187040-44-4
Molecular Formula:C₃₉H₃₈N₂O₈
Molecular Weight:662.739
Hs Code.:

4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester

Synonyms:4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester

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Chemical Property of 4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester

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Technology Process of 4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester

There total 8 articles about 4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 108-23-6
isopropyl chloroformate

: 187040-43-3
1-Benzyl-6-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-3-(4-methoxy-3-methyl-benzyl)-piperazine-2,5-dione

: 187040-44-4
4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; for 3h; Ambient temperature;

Reference yield:

: 80592-18-3
3,4-methylenedioxyphenyl formate

: 187040-44-4
4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 10percent aq. KOH / methanol / 2.5 h / Ambient temperature

2: 56 percent / CF₃COOH / 4 h / Heating

3: 88 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 1 h

4: 78 percent / t-BuOK / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature

5: 100 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) r.t., 2 h

6: 83 percent / NH₂NH₂*H₂O / dimethylformamide / 1 h / Ambient temperature

7: 90 percent / Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; potassium hydroxide; potassium tert-butylate; sodium hydride; hydrazine hydrate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 533-31-3
Sesamol

: 187040-44-4
4-Benzyl-3-[1-(6-benzyloxy-benzo[1,3]dioxol-5-yl)-meth-(Z)-ylidene]-6-(4-methoxy-3-methyl-benzyl)-2,5-dioxo-piperazine-1-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / CF₃COOH / 4 h / Heating

2: 88 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) 0 deg C, 1 h

3: 78 percent / t-BuOK / 2-methyl-propan-2-ol; dimethylformamide / 24 h / Ambient temperature

4: 100 percent / NaH / dimethylformamide / 1.) 0 deg C, 30 min, 2.) r.t., 2 h

5: 83 percent / NH₂NH₂*H₂O / dimethylformamide / 1 h / Ambient temperature

6: 90 percent / Et₃N, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; potassium tert-butylate; sodium hydride; hydrazine hydrate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;