3-(2-phenyl-butyramino)-rutaecarpine

Base Information

• Chemical Name: 3-(2-phenyl-butyramino)-rutaecarpine
• CAS No.: 1443150-20-6
• Molecular Formula: C₂₈H₂₄N₄O₂
• Molecular Weight: 448.524
• Mol file: 1443150-20-6.mol

Synonyms:3-(2-phenyl-butyramino)-rutaecarpine

Chemical Property of 3-(2-phenyl-butyramino)-rutaecarpine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-phenyl-butyramino)-rutaecarpine

There total 7 articles about 3-(2-phenyl-butyramino)-rutaecarpine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-amino-rutaecarpine (1202403-80-2) + 4-Phenylbutyric acid (1821-12-1) → 3-(2-phenyl-butyramino)-rutaecarpine (1443150-20-6)

Guidance literature:

4-Phenylbutyric acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 20 ℃; for 0.5h;

3-amino-rutaecarpine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 48h;

DOI:10.1016/j.ejmech.2013.02.014

Reference yield:

tryptamine (61-54-1) → 3-(2-phenyl-butyramino)-rutaecarpine (1443150-20-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: Reflux

2.1: hydrogenchloride / acetic acid / Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / Reflux

4.1: potassium hydroxide / water; ethanol / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.5 h / 20 °C

5.2: 48 h

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetic acid;

DOI:10.1016/j.ejmech.2013.02.014

Reference yield:

6-nitroisatoic anhydride (4693-02-1) → 3-(2-phenyl-butyramino)-rutaecarpine (1443150-20-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: pyridine / 20 °C

2.1: Reflux

3.1: hydrogenchloride / acetic acid / Reflux

4.1: palladium 10% on activated carbon; hydrogen / methanol / Reflux

5.1: potassium hydroxide / water; ethanol / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.5 h / 20 °C

6.2: 48 h

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; water; acetic acid;

DOI:10.1016/j.ejmech.2013.02.014

upstream raw materials:

3-amino-rutaecarpine

4-Phenylbutyric acid

6-nitroisatoic anhydride

tryptamine

Downstream raw materials:

3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine