3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine

Base Information

• Chemical Name: 3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine
• CAS No.: 1443150-24-0
• Molecular Formula: C₂₈H₂₂N₄O₂
• Molecular Weight: 446.508
• Mol file: 1443150-24-0.mol

Synonyms:3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine

Chemical Property of 3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine

There total 7 articles about 3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-(2-phenyl-butyramino)-rutaecarpine (1443150-20-6) → 3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine (1443150-24-0)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; dimethyl sulfoxide; for 12.5h; Reflux;

DOI:10.1016/j.ejmech.2013.02.014

Reference yield:

tryptamine (61-54-1) → 3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine (1443150-24-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: Reflux

2.1: hydrogenchloride / acetic acid / Reflux

3.1: palladium 10% on activated carbon; hydrogen / methanol / Reflux

4.1: potassium hydroxide / water; ethanol / Reflux

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.5 h / 20 °C

5.2: 48 h

6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane; dimethyl sulfoxide / 12.5 h / Reflux

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetic acid; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2013.02.014

Reference yield:

6-nitroisatoic anhydride (4693-02-1) → 3-(2-phenyl-butyramino)-7,8-dehydrorutaecarpine (1443150-24-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: pyridine / 20 °C

2.1: Reflux

3.1: hydrogenchloride / acetic acid / Reflux

4.1: palladium 10% on activated carbon; hydrogen / methanol / Reflux

5.1: potassium hydroxide / water; ethanol / Reflux

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 0.5 h / 20 °C

6.2: 48 h

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / 1,4-dioxane; dimethyl sulfoxide / 12.5 h / Reflux

With pyridine; hydrogenchloride; palladium 10% on activated carbon; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetic acid; dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2013.02.014

upstream raw materials:

6-nitroisatoic anhydride

tryptamine

3-(2-(1H-indol-3-yl)ethyl)-6-nitro-2-(trifluoromethyl)quinazolin-4(3H)-one

3-nitro-13b-(trifluoromethyl)-13b,14-dihydrorutaecarpine