(R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride

Base Information

Chemical Name:(R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride
CAS No.:1314945-22-6
Molecular Formula:C₂₁H₂₂N₆O₃
Molecular Weight:406.444
Hs Code.:

Synonyms:(R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride

Suppliers and Price of (R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride

There total 7 articles about (R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1314947-55-1
(R)-7-(3-tert-butoxycarbonylaminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine-5-formylic acid

: 1314945-22-6
(R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ml5001905

Reference yield:

: 4966-90-9
4-hydroxy-6-methyl-3-nitro-2(1H)-pyridinone

: 1314945-22-6
(R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / 95 °C / Inert atmosphere

2: sulfuric acid; chromium(VI) oxide / 2.5 h / 60 °C / Inert atmosphere

3: ethanol / 48 h / 20 °C / Inert atmosphere

4: ethanol; water / 48 h / 65 °C / Inert atmosphere

5: potassium hydroxide / tetrahydrofuran; water; diethyl ether / -20 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / methanol / 3 h / Inert atmosphere

7: triethylamine / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

8: potassium carbonate / N,N-dimethyl-formamide / -10 °C / Inert atmosphere

9: water; sodium hydroxide / methanol; dichloromethane / 0 - 20 °C / Inert atmosphere

10: hydrogenchloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With chromium(VI) oxide; hydrogenchloride; sulfuric acid; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; N,N-dimethyl-aniline; triethylamine; potassium hydroxide; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml5001905

Reference yield:

: 1314947-47-1
(R)-1-[2-methoxycarbonyl-5-amino-6-methylaminopyridin-4-yl]piperidine-3-carbamic acid tert-butyl ester

: 1314945-22-6
(R)-7-(3-aminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-formyloxy-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / -10 °C / Inert atmosphere

3: water; sodium hydroxide / methanol; dichloromethane / 0 - 20 °C / Inert atmosphere

4: hydrogenchloride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml5001905