3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride

Base Information

Chemical Name:3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride
CAS No.:603124-21-6
Molecular Formula:C₂₆H₂₆ClNO₅*ClH
Molecular Weight:504.41
Hs Code.:

Synonyms:3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride

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Chemical Property of 3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride

Chemical Property:

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Technology Process of 3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride

There total 14 articles about 3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₄ClNO₇

: 603124-21-6
3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm800222k

Reference yield:

: 132990-84-2
(2S)-N-benzyl-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

: 603124-21-6
3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: boron tribromide / dichloromethane / 4 - 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h

3: ethanol / Reflux

4: tetrahydrofuran / 20 °C

5: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

6: methanol; sodium hydroxide; water / 20 °C

7: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; palladium 10% on activated carbon; water; hydrogen; copper diacetate; boron tribromide; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane;
DOI:10.1021/jm800222k

Reference yield:

: 1048330-11-5
[3-methoxy-5-(methoxycarbonyl)phenyl]boronic acid

: 603124-21-6
3-[((7S)-7-{[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}-5,6,7,8-tetrahydro-2-naphthalenyl)oxy]-5-methoxybenzoic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: copper diacetate; triethylamine / dichloromethane / 20 °C / Molecular sieve; Inert atmosphere

2: methanol; sodium hydroxide; water / 20 °C

3: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; methanol; sodium hydroxide; water; copper diacetate; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm800222k