N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide

Base Information

Chemical Name:N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide
CAS No.:1544673-92-8
Molecular Formula:C₂₉H₃₈BFN₂O₄
Molecular Weight:508.441
Hs Code.:

Synonyms:N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide

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Chemical Property of N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide

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Technology Process of N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide

There total 7 articles about N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 931-53-3
Cyclohexyl isocyanide

: 1544673-68-8
[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine

: 100-52-7
benzaldehyde

: 64-19-7,77671-22-8
acetic acid

: 1544673-92-8
N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide

Guidance literature:: [4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine; benzaldehyde; In methanol; at 50 ℃; for 2h; Microwave irradiation;

Cyclohexyl isocyanide; acetic acid; at 50 ℃; for 2h; Microwave irradiation;
DOI:10.3390/molecules181012346

Reference yield:

: 1544673-52-0
2-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione

: 1544673-92-8
N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine hydrate / tetrahydrofuran / 12 h / Reflux

2.1: methanol / 2 h / 50 °C / Microwave irradiation

2.2: 2 h / 50 °C / Microwave irradiation

With hydrazine hydrate; In tetrahydrofuran; methanol;
DOI:10.3390/molecules181012346

Reference yield:

: 352534-79-3
(2-fluoro-5-formylphenyl)boronic acid

: 1544673-92-8
N-cyclohexyl-2-{N-[4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]acetamido}-2-phenylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium sulfate / methanol / 6 h / 20 °C

2.1: sodium tetrahydroborate / 5 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: hydrazine hydrate / tetrahydrofuran / 12 h / Reflux

6.1: methanol / 2 h / 50 °C / Microwave irradiation

6.2: 2 h / 50 °C / Microwave irradiation

With sodium tetrahydroborate; magnesium sulfate; potassium carbonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3390/molecules181012346