diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate

Base Information

Chemical Name:diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate
CAS No.:700380-77-4
Molecular Formula:C₁₄H₁₈Cl₃O₅P
Molecular Weight:403.627
Hs Code.:

Synonyms:diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate

Chemical Property:

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Technology Process of diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate

There total 4 articles about diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 700380-67-2
diethyl 1-chloro-2-oxo-4-butyryloxy-4-(2,4-dichlorophenyl)butylphosphonate

: 700380-77-4
diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate

: 700380-72-9
diethyl (4S)-1-chloro-2-oxo-4-butyryloxy-4-(2,4-dichlorophenyl)butylphosphonate

Guidance literature:: With pyridine; trichlorosilane; In toluene; for 6h; Heating;
DOI:10.1016/j.jorganchem.2004.06.062

Reference yield:

: 101300-08-7
chloro-1 oxo-2 propylphosphonate de diethyle

: 700380-77-4
diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / n-butyllithium; sodium hydride / tetrahydrofuran; hexane / 1 h / -78 °C

2: 80 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / -10 - 0 °C

3: 41 percent / Candida rugosa lipase; MgCl₂ / diisopropyl ether; H₂O / 48 h / 30 °C

With dmap; n-butyllithium; sodium hydride; dicyclohexyl-carbodiimide; magnesium chloride; Candida rugosa lipase; In tetrahydrofuran; hexane; dichloromethane; di-isopropyl ether; water;
DOI:10.1016/j.tet.2004.02.073

Reference yield:

: 874-42-0
2,4-dichlorobenzaldeyhde

: 700380-77-4
diethyl (4R)-1-chloro-2-oxo-4-hydroxy-4-(2,4-dichlorophenyl)butylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / n-butyllithium; sodium hydride / tetrahydrofuran; hexane / 1 h / -78 °C

2: 80 percent / N,N'-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / -10 - 0 °C

3: 41 percent / Candida rugosa lipase; MgCl₂ / diisopropyl ether; H₂O / 48 h / 30 °C

With dmap; n-butyllithium; sodium hydride; dicyclohexyl-carbodiimide; magnesium chloride; Candida rugosa lipase; In tetrahydrofuran; hexane; dichloromethane; di-isopropyl ether; water;
DOI:10.1016/j.tet.2004.02.073