N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide

Base Information

• Chemical Name: N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide
• CAS No.: 853990-53-1
• Molecular Formula: C₁₆H₂₂FN₃O₃
• Molecular Weight: 323.367
• Mol file: 853990-53-1.mol

Synonyms:N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide

Chemical Property of N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide

There total 3 articles about N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

N-isopropyl alanine (87045-13-4) + [(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamine (278594-24-4) → N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide (853990-53-1)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2005.03.171

Reference yield:

5-nitro-2-fluorotoluene (455-88-9) → N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide (853990-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / NBS / CCl₄ / 18 h / Irradiation

2: 87 percent / tetrahydrofuran / 16 h / 20 °C

3: 68 percent / DCC; HOBT / CH₂Cl₂ / 4 h / 20 °C

With N-Bromosuccinimide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; tetrachloromethane; dichloromethane;

DOI:10.1016/j.tetlet.2005.03.171

Reference yield:

2-fluoro-5-nitrobenzyl bromide (454-15-9) → N-allyl-N-(2-fluoro-5-nitro-benzyl)-2-isopropylamino-propionamide (853990-53-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / tetrahydrofuran / 16 h / 20 °C

2: 68 percent / DCC; HOBT / CH₂Cl₂ / 4 h / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tetlet.2005.03.171

upstream raw materials:

N-isopropyl alanine

[(2-fluoro-5-nitrophenyl)methyl]prop-2-enylamine

5-nitro-2-fluorotoluene

2-fluoro-5-nitrobenzyl bromide