(E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one

Base Information

Chemical Name:(E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one
CAS No.:1262282-71-2
Molecular Formula:C₂₃H₁₃ClO₂
Molecular Weight:356.808
Hs Code.:

Synonyms:(E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one

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Chemical Property of (E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one

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Technology Process of (E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one

There total 3 articles about (E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1262282-53-0
N-methoxy-N-methyl-2,5-bis(phenylethynyl)benzamide

: 1262282-71-2
(E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one

Guidance literature:: With N-chloro-succinimide; copper dichloride; In acetonitrile; at 100 ℃; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol1029035

Reference yield:

: 842135-31-3
5-bromo-2-iodo-N-methoxy-N-methylbenzamide

: 1262282-71-2
(E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine / tetrahydrofuran / 2 h / Inert atmosphere

2: N-chloro-succinimide; copper dichloride / acetonitrile / 100 °C / Inert atmosphere

With N-chloro-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine; copper dichloride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/ol1029035

Reference yield:

: 21740-00-1
5-bromo-2-iodo-benzoic acid

: 1262282-71-2
(E)-3-[chloro(phenyl)methylene]-6-(phenylethynyl)isobenzofuran-1(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

1.2: 12 h / 0 - 25 °C

2.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine / tetrahydrofuran / 2 h / Inert atmosphere

3.1: N-chloro-succinimide; copper dichloride / acetonitrile / 100 °C / Inert atmosphere

With N-chloro-succinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; N-butylamine; N,N-dimethyl-formamide; copper dichloride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/ol1029035