2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

Base Information

Chemical Name:2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile
CAS No.:101544-43-8
Molecular Formula:C₂₅H₂₅N₃O
Molecular Weight:383.493
Hs Code.:

2,3-dihydro-5-<1-hydroxy-2-<bis(phenylmethyl)amino>ethyl>-1H-indole-7-carbonitrile

Synonyms:2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

Suppliers and Price of 2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

There total 8 articles about 2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 101544-42-7
1-acetyl-5-<1-(acetyloxy)-2-ethyl>-2,3-dihydro-1H-indole-7-carbonitrile

: 101544-43-8
2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 1.5h;
DOI:10.1021/jm00156a019

Reference yield:

: 16078-30-1
1-Acetyl-2,3-dihydro-1H-indole

: 101544-43-8
2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) aluminum chloride / 1.) 1,2-dichloroethane, 20 min, 2.) 1,2-dichloroethane, 50 deg C, 1 h

2: dimethylformamide / 2 h / 60 °C

3: NaBH₄ / ethanol / 1.) RT, 4.5 h, 2.) 50 deg C, 1 h

4: 94.5 percent / pyridine / Ambient temperature

5: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature

6: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature

7: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF₄, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h

8: 5N aq. sodium hydroxide / ethanol / 1.5 h / 20 °C

With pyridine; hydrogenchloride; potassium cyanide; sodium hydroxide; sodium tetrahydroborate; tetrafluoroboric acid; aluminium trichloride; nitric acid; acetic acid; zinc; sodium nitrite; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a019

Reference yield:

: 76139-03-2
2-chloro-1-(1-acetyl-2,3-dihydroindole-5-yl)ethanone

: 101544-43-8
2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

Guidance literature:: Multi-step reaction with 7 steps

1: dimethylformamide / 2 h / 60 °C

2: NaBH₄ / ethanol / 1.) RT, 4.5 h, 2.) 50 deg C, 1 h

3: 94.5 percent / pyridine / Ambient temperature

4: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature

5: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature

6: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF₄, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h

7: 5N aq. sodium hydroxide / ethanol / 1.5 h / 20 °C

With pyridine; hydrogenchloride; potassium cyanide; sodium hydroxide; sodium tetrahydroborate; tetrafluoroboric acid; nitric acid; acetic acid; zinc; sodium nitrite; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a019