2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile

Base Information

• Chemical Name: 2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile
• CAS No.: 1012327-20-6
• Molecular Formula: C₁₆H₁₄BrNO₂S₂
• Molecular Weight: 396.329
• Mol file: 1012327-20-6.mol

Synonyms:2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile

Chemical Property of 2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile

There total 4 articles about 2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

thiophene-2-carbodithioic acid methyl ester (2168-83-4) + 2-bromo-4,5-dimethoxyphenylacetonitrile (51655-39-1) + methyl iodide (74-88-4) → 2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile (1012327-20-6)

Guidance literature:

2-bromo-4,5-dimethoxyphenylacetonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;

thiophene-2-carbodithioic acid methyl ester; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃;

DOI:10.1021/ol800029c

Reference yield:

2-bromo-4,5-dimethoxyphenylacetonitrile (51655-39-1) → 2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile (1012327-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide

2: 20 °C

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo501114a

Reference yield:

2-thiophenedithiocarboxylic acid (6135-96-2) → 2-(2-bromo-4,5-dimethoxyphenyl)-3-(methylthio)-3-(thiophen-2-yl)acrylonitrile (1012327-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide

2: 20 °C

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jo501114a

upstream raw materials:

thiophene-2-carbodithioic acid methyl ester

2-bromo-4,5-dimethoxyphenylacetonitrile

methyl iodide

2-thiophenedithiocarboxylic acid

Downstream raw materials:

4,5-dimethoxy-2-(2-(thiophen-2-yl)ethynyl)benzonitrile