4-carboxyphenylalanine hydrochloride

Base Information

• Chemical Name: 4-carboxyphenylalanine hydrochloride
• CAS No.: 80852-33-1
• Molecular Formula: C₁₀H₁₁NO₄*ClH
• Molecular Weight: 245.663
• Mol file: 80852-33-1.mol

Synonyms:4-carboxyphenylalanine hydrochloride

Chemical Property of 4-carboxyphenylalanine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-carboxyphenylalanine hydrochloride

There total 6 articles about 4-carboxyphenylalanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester (52117-01-8) → 4-carboxyphenylalanine hydrochloride (80852-33-1)

Guidance literature:

With hydrogenchloride; at 130 ℃;

DOI:10.1021/jm00035a014

Reference yield: 70.0%

diethyl 2-acetamido-2-<<4-(ethoxycarbonyl)phenyl>methyl>malonate (102321-74-4) → 4-carboxyphenylalanine hydrochloride (80852-33-1)

Guidance literature:

With hydrogenchloride; Reflux;

DOI:10.1007/s00726-010-0594-3

Reference yield:

Ethyl 4-(bromomethyl)benzoate (26496-94-6) → 4-carboxyphenylalanine hydrochloride (80852-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaOEt / 1.) ethanol, 2.) ethanol, 5 h, reflux

2: 1.) aq. NaOH, 2.) acetic acid, 3.) 12 M aq. HCl

With hydrogenchloride; sodium hydroxide; sodium ethanolate; acetic acid;

DOI:10.1021/jm00023a005

upstream raw materials:

N-acetyl-4-cyano-α-(ethoxycarbonyl)phenylalanine ethyl ester

diethyl 2-acetamido-2-<<4-(ethoxycarbonyl)phenyl>methyl>malonate

Ethyl 4-(bromomethyl)benzoate

4-cyanobenzyl bromide

Downstream raw materials:

C₂₇H₂₃N₃O₅

C₂₆H₂₃NO₆

C₁₁H₁₂NO₄^(1-)*Li⁽¹⁺⁾

methyl 4-(2-amino-3-methoxy-3-oxopropyl)benzoate