1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide

Base Information

Chemical Name:1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide
CAS No.:1442425-00-4
Molecular Formula:C₃₁H₄₂N₄O₄S
Molecular Weight:566.765
Hs Code.:

Synonyms:1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide

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Chemical Property of 1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide

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Technology Process of 1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide

There total 8 articles about 1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1442432-62-3
1-(cyclohexylmethyl)-2-methyl-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxylic acid

: 153209-97-3
(3-methyloxetan-3-yl)methanamine

: 1442425-00-4
1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

Reference yield:

: 1442432-59-8
ethyl 1-(cyclohexylmethyl)-2-methyl-5-(3-(pyridin-2-yl)propanoyl)-1H-pyrrole-3-carboxylate

: 1442425-00-4
1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 0.5 h / Dean-Stark; Inert atmosphere; Reflux

2: potassium carbonate / acetonitrile / Reflux

3: potassium tert-butylate; water / dimethyl sulfoxide / 4 h / 85 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

With potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 1442432-57-6
ethyl 5-acetyl-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-carboxylate

: 1442425-00-4
1-(cyclohexylmethyl)-2-methyl-N-((3-methyloxetan-3-yl)methyl)-5-(1-(piperidin-1-ylsulfonyl)indolizin-3-yl)-1H-pyrrole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 72 h / 20 °C

2: palladium on activated charcoal; hydrogen / methanol / 20 °C / 775.74 Torr

3: toluene / 0.5 h / Dean-Stark; Inert atmosphere; Reflux

4: potassium carbonate / acetonitrile / Reflux

5: potassium tert-butylate; water / dimethyl sulfoxide / 4 h / 85 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.33 h / 20 °C

With palladium on activated charcoal; potassium tert-butylate; water; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;