3-OXETANEMETHANAMINE, 3-METHYL-

Base Information

• Chemical Name: 3-OXETANEMETHANAMINE, 3-METHYL-
• CAS No.: 153209-97-3
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• Hs Code.: 2932999099
• Mol file: 153209-97-3.mol

Synonyms:3-Aminomethyl-3-methyloxetane;

Chemical Property of 3-OXETANEMETHANAMINE, 3-METHYL-

Chemical Property:

• Vapor Pressure: 8.076mmHg at 25°C
• Refractive Index: 1.45
• Boiling Point: 134.473 °C at 760 mmHg
• PKA: 9.65±0.29(Predicted)
• Flash Point: 35.528 °C
• PSA: 35.25000
• Density: 0.962 g/cm³
• LogP: 0.68190
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(3-Methyloxetan-3-yl)methanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 10-22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-OXETANEMETHANAMINE, 3-METHYL-

There total 6 articles about 3-OXETANEMETHANAMINE, 3-METHYL- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-hydroxymethyl-3-methyloxethane (3143-02-0) → C10H17NO2 + (3-methyloxetan-3-yl)methanamine (153209-97-3)

Guidance literature:

With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); ammonia; In toluene; for 25h; under 5700.38 Torr; Inert atmosphere; Reflux;

DOI:10.1002/anie.200803229

Reference yield: 81.0%

2-(3-methyloxetan-3-ylmethyl)isoindol-1,3-dione (153004-74-1) → (3-methyloxetan-3-yl)methanamine (153209-97-3)

Guidance literature:

2-(3-methyloxetan-3-ylmethyl)isoindol-1,3-dione; With hydrazine hydrate;

With Raney Ni (W-2); Further stages.;

DOI:10.1021/jo991888g

Reference yield:

C23H24NOP → Triphenylphosphine oxide (791-28-6) + (3-methyloxetan-3-yl)methanamine (153209-97-3)

Guidance literature:

With water; In diethyl ether; for 2h; Yield given; Heating;

DOI:10.1002/(sici)1099-0682(199806)1998:6<675::aid-ejic675>3.0.co;2-m

upstream raw materials:

2-(3-methyloxetan-3-ylmethyl)isoindol-1,3-dione

2-(hydroxymethyl)-2-methylpropane-1,3-diol

methanesulfonic acid 3-methyloxetan-3-ylmethyl ester

3-(azidomethyl)-3-methyloxetane

Downstream raw materials:

N-(3-Methyl-oxetan-3-ylmethyl)-2-phenyl-acetamide

Refernces

• 1、 Gunanathan, Chidambaram,Milstein, David. "Selective synthesis of primary amines directly from alcohols and ammonia". supporting information; experimental part. p. 8661 - 8664. Retrieved 2009/05/15.
• 2、 Nishimura, Tomonari,Kanoh, Shigeyoshi,Senda, Hitoshi,Tanaka, Toshiyuki,Ando, Kohji,Ogawa, Hiroshi,Motoi, Masatoshi. "Chemoselective isomerization of amide-substituted oxetanes with Lewis acid to give oxazine derivatives or bicyclic amide acetals". . p. 43 - 44. Retrieved 2007/10/03.