3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

Base Information

Chemical Name:3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one
CAS No.:1411981-28-6
Molecular Formula:C₂₀H₁₄F₃N₃O₄
Molecular Weight:417.344
Hs Code.:

Synonyms:3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

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Chemical Property of 3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

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Technology Process of 3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

There total 4 articles about 3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411982-50-7
3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one

: 1411981-28-6
3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

Guidance literature:: palladium 10% on activated carbon; In ethyl acetate; for 16h;

Reference yield:

: 1411982-49-4
methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate

: 1411981-28-6
3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 1 h

2: palladium 10% on activated carbon / ethyl acetate / 16 h

With lithium borohydride; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 1411982-25-6
6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

: 1411981-28-6
3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / ISOPROPYLAMIDE / 16 h / 80 °C

2: lithium borohydride / tetrahydrofuran / 1 h

3: palladium 10% on activated carbon / ethyl acetate / 16 h

With lithium borohydride; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; ISOPROPYLAMIDE; ethyl acetate;