methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate

Base Information

• Chemical Name: methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate
• CAS No.: 1411982-49-4
• Molecular Formula: C₂₁H₁₄F₃N₃O₅
• Molecular Weight: 445.354
• Mol file: 1411982-49-4.mol

Synonyms:methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate

Chemical Property of methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate

There total 1 articles about methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one (1411982-25-6) + methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate (208465-72-9) → methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate (1411982-49-4)

Guidance literature:

With potassium carbonate; In ISOPROPYLAMIDE; at 80 ℃; for 16h;

Reference yield:

methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate (1411982-49-4) → 3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one (1411982-50-7)

Guidance literature:

methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate; With lithium borohydride; In tetrahydrofuran; for 1h;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

methyl 2-((4-oxo-6-(4-(trifluoromethoxy)phenyl)quinazolin-3(4H)-yl)methyl)oxazole-4-carboxylate (1411982-49-4) → 3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one (1411981-28-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium borohydride / tetrahydrofuran / 1 h

2: palladium 10% on activated carbon / ethyl acetate / 16 h

With lithium borohydride; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate;

upstream raw materials:

6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

methyl 2-(chloromethyl)-1,3-oxazole-4-carboxylate

Downstream raw materials:

3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)quinazolin-4(3H)-one

3-((4-(hydroxymethyl)oxazol-2-yl)methyl)-6-(4-(trifluoromethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one