9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine

Base Information

Chemical Name:9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine
CAS No.:791111-94-9
Molecular Formula:C₂₈H₃₅N₇O₈
Molecular Weight:597.628
Hs Code.:

Synonyms:9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine

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Chemical Property of 9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine

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Technology Process of 9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine

There total 2 articles about 9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 102728-64-3
9-[(acetoxyethoxy)methyl]guanine

: 47450-18-0,68166-40-5,53331-43-4
N-benzyloxycarbonyl-L-valyl-L-proline

: 791111-94-9
9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine

Guidance literature:: With 2,4,6-trimethyl-pyridine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1016/j.ejmech.2013.10.001

Reference yield: 39.0%

: 791111-93-8
Z-Val-Pro-Cl

: 102728-64-3
9-[(acetoxyethoxy)methyl]guanine

: 791111-94-9
9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine

Guidance literature:: With pyridine; In DMF (N,N-dimethyl-formamide); for 48 - 72h;

Reference yield:

: 791111-94-9
9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl]guanine

: 9-[(2-acetoxyethoxy)methyl]-2-N-[N-(benzyloxycarbonyl)-valyl-prolyl-valyl-prolyl]guanine

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol

2: fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; 2,4,6-trimethyl-pyridine / N,N-dimethyl-formamide / 80 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 1292.9 Torr

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 20 °C

With 2,4,6-trimethyl-pyridine; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.10.001