<<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane

Base Information

Chemical Name:<<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane
CAS No.:133414-00-3
Molecular Formula:C₃₅H₂₈ClFN₃O₃PS
Molecular Weight:656.117
Hs Code.:

Synonyms:<<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane

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Chemical Property of <<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane

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Technology Process of <<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane

There total 14 articles about <<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 133413-97-5
ethyl 2-diazo-2-<2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl>acetate

: 603-35-0
triphenylphosphine

: 133414-00-3
<<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane

Guidance literature:: In di-isopropyl ether; for 20h; Ambient temperature;
DOI:10.1248/cpb.38.3211

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 133414-00-3
<<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane

Guidance literature:: Multi-step reaction with 7 steps

1: 81 percent / SOCl₂ / 1 h / Heating

2: 1.) Mg, CCl₄, EtOH / 1.) Et₂O, reflux, 30 min, 2.) 10 min

3: p-toluenesulfonic acid / H₂O / 2 h / Heating

4: 88 percent / p-toluenesulfonyl azide, Et₃N / acetonitrile / 1 h / Ambient temperature

5: 35 percent / tri-n-butylphosphine / diisopropyl ether / 18 h / Ambient temperature

6: 11 percent / methanol; H₂O / 4.5 h / Heating

7: 83 percent / diisopropyl ether / 20 h / Ambient temperature

With tetrachloromethane; thionyl chloride; 4-toluenesulfonyl azide; ethanol; tributylphosphine; toluene-4-sulfonic acid; magnesium; triethylamine; In methanol; di-isopropyl ether; water; acetonitrile;
DOI:10.1248/cpb.38.3211

Reference yield:

: 120876-32-6
ethyl 2-diazo-3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate

: 133414-00-3
<<1-ethoxycarbonyl-1-(2-chloro-5-fluoro-6-(p-tolylthio)nicotinoyl)methylene>hydrazono>triphenylphosphorane

Guidance literature:: Multi-step reaction with 5 steps

1: 35 percent / tri-n-butylphosphine / diisopropyl ether / 18 h / Ambient temperature

2: 37 percent / KOtBu / dioxane / 2 h / Ambient temperature

3: 85 percent / KOH / ethanol / 1 h / Ambient temperature

4: 89 percent / p-toluenesulfonyl azide, Et₃N / acetonitrile / 0.5 h / Ambient temperature

5: 83 percent / diisopropyl ether / 20 h / Ambient temperature

With potassium hydroxide; 4-toluenesulfonyl azide; tributylphosphine; potassium tert-butylate; triethylamine; In 1,4-dioxane; ethanol; di-isopropyl ether; acetonitrile;
DOI:10.1248/cpb.38.3211