3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline

Base Information

Chemical Name:3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline
CAS No.:1189353-33-0
Molecular Formula:C₂₃H₃₃N₃O₃S
Molecular Weight:431.599
Hs Code.:

Synonyms:3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline

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Chemical Property of 3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline

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Technology Process of 3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline

There total 2 articles about 3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 503-29-7
azetidine

: 1189353-30-7
5-(dimethylamino)-2-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}benzaldehyde

: 1189353-33-0
3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline

Guidance literature:: azetidine; 5-(dimethylamino)-2-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}benzaldehyde; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 20 ℃; Cooling with ice;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 1189351-76-5
methyl 5-(dimethylamino)-2-(7-hydroxy-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)benzoate

: 1189353-33-0
3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 0 °C / Cooling with ice

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Cooling with ice

3: Dess-Martin periodane / dichloromethane / 0 °C / Cooling with ice

4: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 20 °C / Cooling with ice

With lithium aluminium tetrahydride; sodium tris(acetoxy)borohydride; sodium hydride; Dess-Martin periodane; acetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1189353-33-0
3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline

: 1189351-96-9
2-[2-(azetidin-1-ylmethyl)-4-(dimethylamino)phenyl]-4,5,6,7-tetrahydro-1,3-benzothiazol-7-ol

Guidance literature:: 3-(azetidin-1-ylmethyl)-4-{7-[(2-methoxyethoxy)methoxy]-4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl}-N,N-dimethylaniline; With titanium tetrachloride; In dichloromethane; at 0 ℃; Cooling with ice;

With ammonia; water; In dichloromethane;