methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate

Base Information

Chemical Name:methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate
CAS No.:916977-15-6
Molecular Formula:C₁₈H₂₇IO₃Si
Molecular Weight:446.401
Hs Code.:

Synonyms:methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate

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Chemical Property of methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate

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Technology Process of methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate

There total 1 articles about methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 4622-38-2
2-iodobenzyliodide

: 90288-80-5
2-Isopropyl-2-trimethylsilanyloxy-cyclopropanecarboxylic acid methyl ester

: 916977-15-6
methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate

Guidance literature:: 2-Isopropyl-2-trimethylsilanyloxy-cyclopropanecarboxylic acid methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 2h;

2-iodobenzyliodide; In tetrahydrofuran; at -78 ℃; for 36h;
DOI:10.1002/ejoc.200600360

Reference yield: 95.0%

: 916977-15-6
methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate

: 290818-03-0
methyl 2-(2-iodobenzyl)-5-methyl-4-oxopentanoate

Guidance literature:: With triethylamine tris(hydrogen fluoride); In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/S0040-4020(00)00353-7

Reference yield:

: 916977-15-6
methyl 1-(2-iodobenzyl)-2-isopropyl-2-trimethylsiloxycyclopropanecarboxylate

: 224568-40-5
methyl 5-methyl-4-oxo-2-(2-vinylbenzyl)hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / NEt₃*3HF; 2,6-di-tert-butyl-4-methylphenol / CH₂Cl₂ / 3 h / 20 °C

2: 98 percent / 2,6-di-tert-butyl-4-methylphenol / Pd(PPh₃)4 / toluene / Heating

With 2,6-di-tert-butyl-4-methyl-phenol; triethylamine tris(hydrogen fluoride); tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; 2: Stille coupling;
DOI:10.1002/ejoc.200600360