Technology Process of 1-(4-fluorophenyl)-8-methylnaphthalene
There total 3 articles about 1-(4-fluorophenyl)-8-methylnaphthalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 - 140 ℃;
for 1.5h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jo202203r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: boron trifluoride diethyl etherate; sodium cyanoborohydride / tetrahydrofuran / Inert atmosphere
2: tetrakis(triphenylphosphine) palladium(0); caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 - 140 °C / Inert atmosphere; Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); boron trifluoride diethyl etherate; sodium cyanoborohydride; caesium carbonate;
In
tetrahydrofuran; N,N-dimethyl-formamide;
2: Suzuki-Miyaura coupling;
DOI:10.1021/jo202203r
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: methyllithium / tetrahydrofuran; diethyl ether / 0.62 h / 0 °C / Inert atmosphere
1.2: 3 h / 0 - 22 °C / Inert atmosphere
2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0) / toluene / Schlenk technique; Inert atmosphere; Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); methyllithium;
In
tetrahydrofuran; diethyl ether; toluene;
2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.joc.6b01858
