2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

Base Information

• Chemical Name: 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester
• CAS No.: 90961-43-6
• Molecular Formula: C₁₂H₁₁ClO₃
• Molecular Weight: 238.671
• Mol file: 90961-43-6.mol

Synonyms:2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

Chemical Property of 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester

There total 1 articles about 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetoacetic acid methyl ester (105-45-3) + m-Chlorobenzaldehyde (587-04-2) → 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester (90961-43-6)

Guidance literature:

With piperidine; acetic acid; In benzene; for 2h; Heating;

DOI:10.1248/cpb.41.108

Reference yield: 77.2%

(Z)-3-Amino-but-2-enoic acid 2-cyano-ethyl ester (193539-61-6) + 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester (90961-43-6) → 4-(3-Chloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester (147597-24-8)

Guidance literature:

In isopropyl alcohol; for 3h;

DOI:10.1248/cpb.41.108

Reference yield: 65.0%

[bromo(difluoro)methyl]-trimethyl-silane (115262-01-6) + 2-[1-(3-Chloro-phenyl)-meth-(Z)-ylidene]-3-oxo-butyric acid methyl ester (90961-43-6) → methyl 5-(3-chlorophenyl)-3,3-difluoro-2-hydroxycyclopent-1-ene-1-carboxylate

Guidance literature:

With tetrabutylammomium bromide; In acetonitrile; at 100 ℃; for 8h; Schlenk technique;

DOI:10.1021/acs.orglett.7b00611

upstream raw materials:

acetoacetic acid methyl ester

m-Chlorobenzaldehyde

Downstream raw materials:

4-(3-Chloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester

4-(3-chloro-phenyl)-2-methoxy-6-methyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester

6-(3-chlorophenyl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine

(-)-2,6-dimethyl-3-carbomethoxy-4-(3-chlorophenyl)-5-carboxy-1,4-dihydropyridine