2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol

Base Information

• Chemical Name: 2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol
• CAS No.: 1094597-72-4
• Molecular Formula: C₁₅H₁₃N₅O₂S
• Molecular Weight: 327.367
• Mol file: 1094597-72-4.mol

Synonyms:2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol

Chemical Property of 2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol

There total 4 articles about 2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + 4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol (36209-51-5) → 2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol (1094597-72-4)

Guidance literature:

With sulfuric acid; In ethanol; Reflux;

DOI:10.1016/j.saa.2008.05.003

Reference yield:

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + 3-(pyridin-4-yl)-5-mercapto-4H-1,2,4-triazole (1477-24-3) → 2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol (1094597-72-4)

Guidance literature:

In acetic acid; for 6h; Reflux;

DOI:10.1016/j.saa.2016.08.008

Reference yield:

isoniazid (54-85-3,7640-37-1) → 2-(((3-mercapto-5-(pyridin-4-yl)-4H-1,2,4-triazol-4-yl)imino)methyl)-5-methoxyphenol (1094597-72-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol

2: hydrazine hydrate / ethanol

3: acetic acid / 6 h / Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol; acetic acid;

DOI:10.1016/j.saa.2016.08.008

upstream raw materials:

2-Hydroxy-4-methoxybenzaldehyde

4-amino-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol

isoniazid

potassium 4-pyridinyldithiocarbazate