2-[5-(3-trifluoromethyl-6-chloro-phen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4-tetrahydro-β-carboline

Base Information

Chemical Name:2-[5-(3-trifluoromethyl-6-chloro-phen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4-tetrahydro-β-carboline
CAS No.:1620099-77-5
Molecular Formula:C₂₃H₁₆ClF₃N₂O₂
Molecular Weight:444.84
Hs Code.:

Synonyms:2-[5-(3-trifluoromethyl-6-chloro-phen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4-tetrahydro-β-carboline

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Chemical Property of 2-[5-(3-trifluoromethyl-6-chloro-phen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4-tetrahydro-β-carboline

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Technology Process of 2-[5-(3-trifluoromethyl-6-chloro-phen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4-tetrahydro-β-carboline

There total 2 articles about 2-[5-(3-trifluoromethyl-6-chloro-phen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4-tetrahydro-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 16502-01-5
tetrahydrobetacarboline

: 753499-38-6
C₁₂H₅Cl₂F₃O₂

: 1620099-77-5
2-[5-(3-trifluoromethyl-6-chloro-phen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4-tetrahydro-β-carboline

Guidance literature:: tetrahydrobetacarboline; With sodium hydroxide; In dichloromethane; water; at 0 ℃; for 0.0833333h;

C₁₂H₅Cl₂F₃O₂; In dichloromethane; water; at 0 - 20 ℃; for 3.25h;
DOI:10.1016/j.bmcl.2014.06.030

Reference yield:

: 302911-88-2
5-(2-chloro-5-trifluoromethylphenyl)furan-2-carboxylic acid

: 1620099-77-5
2-[5-(3-trifluoromethyl-6-chloro-phen-1-yl)-furan-2-yl-carbonyl]-1,2,3,4-tetrahydro-β-carboline

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / benzene / 0.5 h / 0 °C

2.1: sodium hydroxide / dichloromethane; water / 0.08 h / 0 °C

2.2: 3.25 h / 0 - 20 °C

With thionyl chloride; sodium hydroxide; In dichloromethane; water; benzene;
DOI:10.1016/j.bmcl.2014.06.030