(+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one

Base Information

Chemical Name:(+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one
CAS No.:944128-21-6
Molecular Formula:C₁₈H₂₆N₂O₃
Molecular Weight:318.416
Hs Code.:

Synonyms:(+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one

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Chemical Property of (+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one

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Technology Process of (+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one

There total 5 articles about (+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 944128-16-9
(+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)-5,6-dihydro-1H-pyridin-2-one

: 944128-21-6
(+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 12h; under 760.051 Torr;
DOI:10.1021/ol070757w

Reference yield:

: 59983-39-0,187035-29-6
(S)-1-amino-2-(methoxymethyl)pyrrolidine

: 944128-21-6
(+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / MgSO₄ / CH₂Cl₂ / 12 h / 20 °C

2.1: PhLi / diethyl ether; dibutyl ether / 0.5 h / 20 °C

2.2: diethyl ether; dibutyl ether / -78 - 20 °C

2.3: 54 percent / diethyl ether; dibutyl ether / -78 - 20 °C

3.1: 75 percent / second generation Grubbs catalyst / CH₂Cl₂ / 24 h / 20 °C

4.1: 98 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C / 760.05 Torr

With hydrogen; magnesium sulfate; phenyllithium; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; dibutyl ether;
DOI:10.1021/ol070757w

Reference yield:

: 944128-11-4
(-)-(1R,2S)-N-(2-methoxymethylpyrrolidin-1-yl)-N-[1-(4-methoxyphenyl)but-3-enyl]acrylamide

: 944128-21-6
(+)-(6R,2S)-1-(2-methoxymethylpyrrolidin-1-yl)-6-(4-methoxyphenyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / second generation Grubbs catalyst / CH₂Cl₂ / 24 h / 20 °C

2: 98 percent / H₂ / Pd/C / ethanol / 12 h / 20 °C / 760.05 Torr

With hydrogen; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/ol070757w