5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione

Base Information

• Chemical Name: 5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione
• CAS No.: 1373621-13-6
• Molecular Formula: C₂₅H₂₆N₂O₈
• Molecular Weight: 482.49
• Mol file: 1373621-13-6.mol

Synonyms:5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione

Chemical Property of 5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione

There total 3 articles about 5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

carbon monoxide (201230-82-2) + 2-iodophenylamine (615-43-0) + ethyl 2-ethoxycarbonyl-3-trifluoromethylpropenoate (152500-10-2) → diethyl 2-ethoxycarbonyl-3-(2-iodophenylamino)butandienoate (1373621-15-8) + 5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione (1373621-13-6) + 2,3,3-triethoxycarbonyl-2,3-dihydro-4(1H)-quinolinone (14370-77-5)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; johnphos; In acetonitrile; at 80 ℃; for 20h; under 25858.1 Torr;

DOI:10.1021/jo300173g

Reference yield: 68.0%

diethyl 2-(ethoxycarbonylmethylene)malonate (13049-86-0) + carbon monoxide (201230-82-2) + 2-iodophenylamine (615-43-0) → diethyl 2-ethoxycarbonyl-3-(2-iodophenylamino)butandienoate (1373621-15-8) + 5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione (1373621-13-6) + 2,3,3-triethoxycarbonyl-2,3-dihydro-4(1H)-quinolinone (14370-77-5)

Guidance literature:

With triethylamine; tricyclohexylphosphine tetrafluoroborate; at 80 ℃;

DOI:10.1021/jo300173g

Reference yield: 54.0%

diethyl 2-(ethoxycarbonylmethylene)malonate (13049-86-0) + carbon monoxide (201230-82-2) + 2-iodophenylamine (615-43-0) → diethyl 2-ethoxycarbonyl-3-(2-iodophenylamino)butandienoate (1373621-15-8) + 5-(1,2,2-triethoxycarbonylethyl)dibenzo[b,f][1,5]diazocine-6,12-(5H,11H)dione (1373621-13-6)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; at 80 ℃;

DOI:10.1021/jo300173g

upstream raw materials:

diethyl 2-(ethoxycarbonylmethylene)malonate

carbon monoxide

2-iodophenylamine

ethyl 2-ethoxycarbonyl-3-trifluoromethylpropenoate