tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester

Base Information

Chemical Name:tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester
CAS No.:441790-60-9
Molecular Formula:C₂₃H₂₇N₅O₃
Molecular Weight:421.499
Hs Code.:

Synonyms:tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester

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Chemical Property of tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester

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Technology Process of tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester

There total 5 articles about tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 441790-59-6
C₁₈H₂₄N₄O₃

: 7379-35-3
4-chlorpyridine hydrochloride

: 441790-60-9
tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 150 - 160 ℃; for 2h;
DOI:10.1248/cpb.54.1535

Reference yield:

: 318988-51-1
N-(2-oxoethyl)-N-[(phenylmethoxy)carbonyl]glycine ethyl ester

: 441790-60-9
tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / toluene / 6 h / Heating

2.1: 1,8-bis(dimethylamino)naphthalene; α-chloroethyl chloroformate / 1,2-dichloro-ethane / 1 h / 20 °C

2.2: 82 percent / methanol / 1 h / Heating

3.1: 55 percent / i-Pr₂NEt / ethanol / 2 h / 150 - 160 °C

With carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; N-ethyl-N,N-diisopropylamine; In ethanol; 1,2-dichloro-ethane; toluene;
DOI:10.1248/cpb.54.1535

Reference yield:

: 441790-58-5
tetrahydro-5-oxo-1'-(phenylmethyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester

: 441790-60-9
tetrahydro-5-oxo-1'-(4-pyridinyl)spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidine]-7(1H)-carboxylic acid phenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-bis(dimethylamino)naphthalene; α-chloroethyl chloroformate / 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 82 percent / methanol / 1 h / Heating

2.1: 55 percent / i-Pr₂NEt / ethanol / 2 h / 150 - 160 °C

With carbonochloridic acid 1-chloro-ethyl ester; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; N-ethyl-N,N-diisopropylamine; In ethanol; 1,2-dichloro-ethane;
DOI:10.1248/cpb.54.1535