(2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid

Base Information

Chemical Name:(2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid
CAS No.:910230-89-6
Molecular Formula:C₂₆H₃₆ClNO₅Si
Molecular Weight:506.114
Hs Code.:

Synonyms:(2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid

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Chemical Property of (2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid

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Technology Process of (2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid

There total 2 articles about (2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 910230-88-5
(2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide

: 910230-89-6
(2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid

Guidance literature:: With chromium(VI) oxide; water; periodic acid; In acetonitrile; at 0 ℃; for 0.5h;
DOI:10.1021/ja0625834

Reference yield:

: 477351-74-9
(R)-3-(tert-butyldiphenylsilyloxy)-2-methoxypropionic acid

: 910230-89-6
(2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 0.56 g / 2,6-lutidine; PyBOP / CH₂Cl₂ / 18 h / 20 °C

2: 78 percent / CrO₃; H₅IO₆; H₂O / acetonitrile / 0.5 h / 0 °C

With 2,6-dimethylpyridine; chromium(VI) oxide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; periodic acid; In dichloromethane; acetonitrile;
DOI:10.1021/ja0625834

Reference yield: 57.0%

: 910230-89-6
(2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid

: 477351-62-5
methyl (2S,5S,6S,3aR,7aS)-5,6-bis(methoxymethoxy)octahydroindole-2-carboxylate

: 910230-92-1
(2S,3aR,5S,6S,7aS)-1-{(2S,3R)-2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methoxy-propionylamino]-3-chloro-4-methyl-pentanoyl}-5,6-bis-methoxymethoxy-octahydro-indole-2-carboxylic acid methyl ester

Guidance literature:: With 2,6-dimethylpyridine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In dichloromethane; at 0 ℃; for 4h;
DOI:10.1021/ja0625834