(2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide

Base Information

Chemical Name:(2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide
CAS No.:910230-88-5
Molecular Formula:C₂₆H₃₈ClNO₄Si
Molecular Weight:492.131
Hs Code.:

Synonyms:(2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide

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Chemical Property of (2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide

Chemical Property:

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Technology Process of (2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide

There total 1 articles about (2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R)-2-Amino-3-chloro-4-methyl-pentan-1-ol; compound with trifluoro-methanesulfonic acid

: 477351-74-9
(R)-3-(tert-butyldiphenylsilyloxy)-2-methoxypropionic acid

: 910230-88-5
(2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide

Guidance literature:: With 2,6-dimethylpyridine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1021/ja0625834

Reference yield: 78.0%

: 910230-88-5
(2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide

: 910230-89-6
(2S,3R,2'R)-2-[3'-(tert-butyldiphenylsilyloxy)-2'-methoxypropionylamino]-3-chloro-4-methylpentanoic acid

Guidance literature:: With chromium(VI) oxide; water; periodic acid; In acetonitrile; at 0 ℃; for 0.5h;
DOI:10.1021/ja0625834

Reference yield:

: 910230-88-5
(2R,1'S,2'R)-3-(tert-butyldiphenylsilyloxy)-N-(2'-chloro-1'-hydroxymethyl-3'-methylbutyl)-2-methoxypropionamide

: 910230-92-1
(2S,3aR,5S,6S,7aS)-1-{(2S,3R)-2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methoxy-propionylamino]-3-chloro-4-methyl-pentanoyl}-5,6-bis-methoxymethoxy-octahydro-indole-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 48 percent / 1,4-bis(diphenylphosphino)butane; diisopropylethylamine / Pd(OAc)2 / dimethylsulfoxide / 4 h / 100 °C

2.1: 95 percent / BBr₃ / CH₂Cl₂ / 48 h / 20 °C

3.1: K₂CO₃ / dimethylformamide / 0.5 h / 20 °C

3.2: 87 percent / dimethylformamide / 50 °C

With boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium diacetate; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/adsc.200606143