Technology Process of ethyl 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)benzoate
There total 7 articles about ethyl 4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 50 °C
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene; ethanol / 100 °C
3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethyl acetate / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine;
In
tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide; toluene;
2: |Suzuki Coupling;
- Guidance literature:
-
With
palladium 10% on activated carbon; hydrogen;
In
tetrahydrofuran; ethyl acetate;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
1.2: 20 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium acetate / 1,4-dioxane / 100 °C / Inert atmosphere
3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / toluene; ethanol / 100 °C
4.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethyl acetate / 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; hydrogen; sodium acetate; sodium hexamethyldisilazane; potassium carbonate;
In
tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate; toluene;
3.1: |Suzuki Coupling;
