85331-33-5

Basic information

• Product Name: 3,5-Dichloro-2-cyanopyridine
• Synonyms: 2-PYRIDINECARBONITRILE, 3,5-DICHLORO-;2-CYANO-3,5-DICHLOROPYRIDINE;3,5-DICHLORO-2-CYANOPYRIDINE;3,5-Dichloropicolinitrile;3,5-Dichloropyridine-2-carbonitrile;3,5-dichloropicolinonitrile;Cyanodichloropyridine 235---;2-Cyano-3,5-dichloropyridine, 3,5-Dichloropicolinonitrile
• CAS NO: 85331-33-5
• Molecular Formula: C₆H₂Cl₂N₂
• Molecular Weight: 173
• EINECS: -0
• Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Pyridine series;Pyridines;Pyridine;Pyridines derivates;Building Blocks;C6;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 85331-33-5.mol

Chemical Properties

• Melting Point: 101-103°C
• Boiling Point: 271.9 °C at 760 mmHg
• Flash Point: 118.2 °C
• Appearance: yellow powder
• Density: 1.49 g/cm³
• Vapor Pressure: 0.00627mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Room temperature.
• PKA: -4.61±0.10(Predicted)
• BRN: 4390101
• CAS DataBase Reference: 3,5-Dichloro-2-cyanopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichloro-2-cyanopyridine(85331-33-5)
• EPA Substance Registry System: 3,5-Dichloro-2-cyanopyridine(85331-33-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-36-36/37
• RIDADR: 3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 85331-33-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H2Cl2N2/c7-4-1-5(8)6(2-9)10-3-4/h1,3H

Upstream product

• 15177-57-8 3,5-dicholoropyridine N-oxide 
• 7677-24-9 trimethylsilyl cyanide 
• 16063-70-0 2,3,5-trichloropyridine 
• 2457-47-8 3,5-dichloropyridine 
• 14482-51-0 3,5-dichloro-2-bromopyridine 
• 823-56-3 2-Fluoro-3,5-dichloropyridine 

Downstream Products

• 298709-32-7 amino(3,5-difluoropyridin-2-yl)methaniminium chloride 
• 298709-29-2 3,5-difluoropyridine-2-carbonitrile 
• 81719-53-1 3,5-dichloropyridine-2-carboxylic acid 
• 1186637-62-6 3-chloro-5-((4-ethoxyphenyl)ethynyl)picolinonitrile 
• 1186638-12-9 3-chloro-5-((4-propoxyphenyl)ethynyl)picolinonitrile 
• 1186638-02-7 ethyl 4-((5-chloro-6-cyanopyridin-3-yl)ethynyl)benzoate 
• 1186637-50-2 (E)-3-chloro-5-(3-methoxyprop-1-enyl)picolinonitrile 
• 1186637-47-7 3-chloro-5-vinylpicolinonitrile 
• 1186637-48-8 3-chloro-5-phenylpicolinonitrile 
• 1186637-49-9 (E)-3-chloro-5-styrylpicolinonitrile 
• 1186637-60-4 5-((1H-indol-5-yl)ethynyl)-3-chloropicolinonitrile 
• 1186638-04-9 3-chloro-5-(p-tolylethynyl)picolinonitrile 
• 1186637-51-3 3-chloro-5-(prop-1-en-2-yl)picolinonitrile 
• 1186637-58-0 (E)-3-chloro-5-(prop-1-enyl)picolinonitrile 

Relevant articles and documents

Synthesis method of 3, 5-dichloro-2-cyanopyridine

The invention provides a synthesis method of 3, 5-dichloro-2-cyanopyridine. The method includes the steps of: 1) in the presence of a solvent, mixing 2, 3, 5-trichloropyridine with a fluoride for reaction to obtain 3, 5-dichloro-2-fluoropyridine; and 2) mixing the 3, 5-dichloro-2-fluoropyridine prepared in step 1) with a catalyst and a cyanide salt for reaction to obtain 3, 5-dichloro-2-cyanopyridine. The method provided by the invention uses sodium cyanide, potassium cyanide or other cheap and easily available cyanide salts as the cyaniding reagent with a dosage far lower than that of the existing method, and can acquire the target product with high yield and high content, thereby greatly reducing the production cost, also greatly reducing the production of wastewater in the three wastes,and being an efficient and environment-friendly production method of 3, 5-dichloro-2-cyanopyridine.

3. 5 - Dichloro -2 - cyano pyridine synthesis method

The invention provides a method for 2, 3, 5 - trichloro-pyridine as the starting material, in order to organic acid as solvent, bromide reaction process for preparing the intermediate 2 - bromo - 3, 5 - chlorinate, then in the organic solvent and the presence of a catalyst reaction with cuprous cyanide, prepared by the organic solvent refining after 3, 5 - dichloro - 2 - cyano pyridine, the purity of the product ≥ 99.0%. The reaction raw materials are cheap and easy to obtain, there are few reaction steps, high-purity product, post-processing procedure is greatly simplified, and the acetic acid such as ethyl organic solvent can be repeatedly recycles the wrap, small pollution, safety, help to realize commercial process.

Medicaments against viral diseases

Novel dihydropyrimidines and combinations thereof with other antiviral agents, suitable for combating HBV infections.

Benzopyranopyrrole and benzopyranopyridine alpha -1 adrenergic compounds

The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.

Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds

The present invention relates to a compound of the formula STR1 and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are α-1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are α-1 antagonist compositions and a method for antagonizing α-1 adrenoreceptors and tr

Pyridine derivatives, their production and use

Pyridine derivatives of the formula STR1 wherein the ring A stands for an optionally further substituted benzene ring; the ring B stands for an optionally substituted pyridine ring; Q stands for hydroxyl group, or OQ 1 or Q 1 wherein Q 1 stands for an optionally substituted aliphatic hydrocarbon group; and n denotes 0 or 1, or their salts, which have potassium.channel opening activity and are useful as therapeutic agents of circulatory diseases such as angina pectoris, hypertension, etc.