tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate
CAS No.:911417-67-9
Molecular Formula:C₃₂H₃₅N₇O₄
Molecular Weight:581.674
Hs Code.:

Synonyms:tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Technology Process of tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

There total 7 articles about tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 911417-67-9
tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: pyridine / chloroform / 6 h / 20 °C

2.1: sodium hydroxide / water / 4 h / Heating / reflux

2.2: 2 h / 20 °C / pH 7

3.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C

3.2: 0.5 h / -78 - 20 °C

3.3: pH 7

4.1: pyridine / 3.5 h / 105 °C

5.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Heating / reflux

6.1: isopropyl alcohol / 0.5 h / 95 °C

7.1: methanol; ammonia; water / 48 h / 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

With pyridine; methanol; sodium hydroxide; thionyl chloride; ammonia; water; boron tribromide; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 911417-26-0
tert-butyl 5-(2-(3-hydroxyphenyl)-quinazolin-4-ylamino)-1H-indazole-1-carboxylate

: 2-chloro-N-(2-(dimethylamino)ethyl)acetamide

: 911417-67-9
tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

Reference yield:

: 911417-24-8
3-(4-chloroquinazolin-2-yl)phenyl acetate

: 911417-67-9
tert-butyl 5-(2-(3-(2-(2-(dimethylamino)-ethylamino)-2-oxoethoxy)phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 0.5 h / 95 °C

2: methanol; ammonia; water / 48 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

With methanol; ammonia; water; potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;