tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Base Information

Chemical Name:tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate
CAS No.:911417-25-9
Molecular Formula:C₂₈H₂₅N₅O₄
Molecular Weight:495.538
Hs Code.:

Synonyms:tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Chemical Property of tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

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Technology Process of tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

There total 6 articles about tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 129488-10-4
5-Amino-indazole-1-carboxylic acid tert-butyl ester

: 911417-24-8
3-(4-chloroquinazolin-2-yl)phenyl acetate

: 911417-25-9
tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: In isopropyl alcohol; at 95 ℃; for 0.25h;

Reference yield:

: 28144-70-9,88-68-6
anthranilic acid amide

: 911417-25-9
tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / chloroform / 6 h / 20 °C

2.1: sodium hydroxide / water / 4 h / Heating / reflux

2.2: 2 h / 20 °C / pH 7

3.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C

3.2: 0.5 h / -78 - 20 °C

3.3: pH 7

4.1: pyridine / 3.5 h / 105 °C

5.1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Heating / reflux

6.1: isopropyl alcohol / 0.5 h / 95 °C

With pyridine; sodium hydroxide; thionyl chloride; boron tribromide; N,N-dimethyl-formamide; In dichloromethane; chloroform; water; isopropyl alcohol;

Reference yield:

: 911417-23-7
2-(3-hydroxylphenyl)quinazolin-4(3H)-one

: 911417-25-9
tert-butyl 5-(2-(3-acetoxyphenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 3.5 h / 105 °C

2: thionyl chloride; N,N-dimethyl-formamide / 4 h / Heating / reflux

3: isopropyl alcohol / 0.5 h / 95 °C

With pyridine; thionyl chloride; N,N-dimethyl-formamide; In isopropyl alcohol;