4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide

Base Information

• Chemical Name: 4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide
• CAS No.: 1445797-07-8
• Molecular Formula: C₂₀H₂₃ClN₂O₃
• Molecular Weight: 374.867

Synonyms:4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide

Chemical Property of 4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

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Technology Process of 4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide

There total 2 articles about 4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

1-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]-methylamine (440087-51-4) + ethyl-2-chloro-4-amino-benzoate (16017-69-9) → 4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide (1445797-07-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 41.0%

1-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]-methylamine (440087-51-4) + 4-amino-2-chlorobenzoic acid (2457-76-3) → 4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide (1445797-07-8)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;

Reference yield: 77.0%

4-amino-2-chloro-N-[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]benzamide (1445797-07-8) + 5-methyl-1,3,4-oxadiazole-2-carboxylic acid ethyl ester (37641-36-4) → 5-methyl-[1,3,4]oxadiazole-2-carboxylic acid (3-chloro-4-{[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]carbamoyl}phenyl)amide (1445797-05-6)

Guidance literature:

With trimethylaluminum; In toluene; at 20 ℃; for 2h; Reflux;

upstream raw materials:

1-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]-methylamine

ethyl-2-chloro-4-amino-benzoate

4-amino-2-chlorobenzoic acid

Downstream raw materials:

5-methyl-[1,3,4]oxadiazole-2-carboxylic acid (3-chloro-4-{[4-(4-methoxyphenyl)tetrahydropyran-4-ylmethyl]carbamoyl}phenyl)amide

C₂₅H₂₆ClN₃O₅

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