(R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Base Information

Chemical Name:(R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate
CAS No.:125729-30-8
Molecular Formula:C₂₀H₂₂Cl₂N₂O₆
Molecular Weight:457.31
Hs Code.:

Synonyms:(R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

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Chemical Property of (R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

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Technology Process of (R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

There total 12 articles about (R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1189-71-5
isocyanate de chlorosulfonyle

: 144686-69-1
(R)-isopropyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2-hydroxymethyl-3-methoxycarbonyl-6-methyl-5-pyridinecarboxylate

: 125729-30-8
(R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Guidance literature:: In dichloromethane; at 0 ℃;
DOI:10.1248/cpb.45.869

Reference yield:

: 134969-44-1
isopropyl 4-bromo-3-oxobutanoate

: 125729-30-8
(R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / AcOH / 18 h / 90 °C

2: 43 percent / propan-2-ol / 18 h / Heating

3: cholesterol esterase, H₂O / acetone; diisopropyl ether / 72 h

4: 72 percent / CH₂Cl₂ / 0 °C

With cholesterol esterase; water; acetic acid; In dichloromethane; di-isopropyl ether; isopropyl alcohol; acetone;
DOI:10.1248/cpb.45.869

Reference yield:

: 144686-67-9
isopropyl 4-acetoxyacetoacetate

: 125729-30-8
(R)-isopropyl 1,4-dihydro-2-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-5-methoxycarbonyl-6-methyl-3-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / propan-2-ol / 18 h / Heating

2: cholesterol esterase, H₂O / acetone; diisopropyl ether / 72 h

3: 72 percent / CH₂Cl₂ / 0 °C

With cholesterol esterase; water; In dichloromethane; di-isopropyl ether; isopropyl alcohol; acetone;
DOI:10.1248/cpb.45.869