Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine

Base Information

Chemical Name:Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine
CAS No.:372965-98-5
Molecular Formula:C₄₁H₅₃N₃OSi
Molecular Weight:631.977
Hs Code.:

Synonyms:Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine

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Chemical Property of Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine

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Technology Process of Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine

There total 3 articles about Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1013-88-3
Benzophenone imine

: 372965-97-4
Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester

: 372965-98-5
Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In tetrahydrofuran; at 70 ℃; for 23h;
DOI:10.1021/ol016577i

Reference yield:

: dihydrocupreidine

: 372965-98-5
Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / DMAP; 2,4,6-collidine / CH₂Cl₂ / 24 h / Heating

2: 90 percent / i-Pr₂NEt / CH₂Cl₂ / 3 h / 23 °C

3: 91 percent / BINAP; Cs₂CO₃ / Pd(OAc)2 / tetrahydrofuran / 23 h / 70 °C

With 2,4,6-trimethyl-pyridine; dmap; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; palladium diacetate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol016577i

Reference yield:

: 372966-04-6
dihydrocupreidine monotriflate

: 372965-98-5
Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / i-Pr₂NEt / CH₂Cl₂ / 3 h / 23 °C

2: 91 percent / BINAP; Cs₂CO₃ / Pd(OAc)2 / tetrahydrofuran / 23 h / 70 °C

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; palladium diacetate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol016577i