Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester
CAS No.:372965-97-4
Molecular Formula:C₂₉H₄₃F₃N₂O₄SSi
Molecular Weight:600.818
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester

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Technology Process of Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester

There total 1 articles about Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 372966-04-6
dihydrocupreidine monotriflate

: 372965-97-4
Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 3h;
DOI:10.1021/ol016577i

Reference yield: 91.0%

: 1013-88-3
Benzophenone imine

: 372965-97-4
Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester

: 372965-98-5
Benzhydrylidene-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl}-amine

Guidance literature:: With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In tetrahydrofuran; at 70 ℃; for 23h;
DOI:10.1021/ol016577i

Reference yield:

: 372965-97-4
Trifluoro-methanesulfonic acid 4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-triisopropylsilanyloxy-methyl]-quinolin-6-yl ester

: 372965-96-3
N-Benzhydryl-N-{4-[(S)-((2R,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-hydroxy-methyl]-quinolin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / BINAP; Cs₂CO₃ / Pd(OAc)2 / tetrahydrofuran / 23 h / 70 °C

2: NaCNBH₃ / acetic acid / 5.5 h / 23 °C

3: pyridine / 2 h / 23 °C

4: 1.26 g / TBAF / tetrahydrofuran / 1 h / 23 °C

With pyridine; tetrabutyl ammonium fluoride; sodium cyanoborohydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In tetrahydrofuran; acetic acid;
DOI:10.1021/ol016577i