benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate

Base Information

Chemical Name:benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate
CAS No.:1309236-59-6
Molecular Formula:C₃₈H₄₉NO₄
Molecular Weight:583.811
Hs Code.:

benzyl 12-oxo-isoxazolo[4,5-b]olean-9<sup>(11)</sup>-en-28-oate

Synonyms:benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate

Suppliers and Price of benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate

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Chemical Property of benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate

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Technology Process of benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate

There total 10 articles about benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: benzyl 2-hydroxymethylene-3,12-dioxo-olean-9⁽¹¹⁾-en-28-oate

: 1309236-59-6
benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate

Guidance literature:: With hydroxylamine hydrochloride; In ethanol; water; for 1h; Reflux;
DOI:10.1021/jm5020023

Reference yield:

: 508-02-1
Oleanolic acid

: 1309236-59-6
benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C

2: pyridine / 4 h / 20 °C

3: dihydrogen peroxide; formic acid / dichloromethane / 24 h / 20 °C

4: hydrogen bromide; acetic acid; bromine / 24 h / 20 - 50 °C

5: potassium hydroxide / methanol / 0.75 h / Reflux

6: Jones reagent / acetone / 0.33 h / 0 - 20 °C

7: sodium methylate / dichloromethane / 2 h / 20 °C

8: hydroxylamine hydrochloride / ethanol; water / 1 h / Reflux

With pyridine; Jones reagent; formic acid; hydroxylamine hydrochloride; hydrogen bromide; dihydrogen peroxide; bromine; sodium methylate; potassium carbonate; acetic acid; potassium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 6: |Jones Oxidation;
DOI:10.1021/jm5020023

Reference yield:

: 303114-51-4
oleanolic acid benzyl ester

: 1309236-59-6
benzyl 12-oxo-isoxazolo[4,5-b]olean-9⁽¹¹⁾-en-28-oate

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / 4 h / 20 °C

2: dihydrogen peroxide; formic acid / dichloromethane / 24 h / 20 °C

3: hydrogen bromide; acetic acid; bromine / 24 h / 20 - 50 °C

4: potassium hydroxide / methanol / 0.75 h / Reflux

5: Jones reagent / acetone / 0.33 h / 0 - 20 °C

6: sodium methylate / dichloromethane / 2 h / 20 °C

7: hydroxylamine hydrochloride / ethanol; water / 1 h / Reflux

With pyridine; Jones reagent; formic acid; hydroxylamine hydrochloride; hydrogen bromide; dihydrogen peroxide; bromine; sodium methylate; acetic acid; potassium hydroxide; In methanol; ethanol; dichloromethane; water; acetone; 5: |Jones Oxidation;
DOI:10.1021/jm5020023