1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Base Information

Chemical Name:1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole
CAS No.:218297-83-7
Molecular Formula:C₂₆H₂₂N₆O₃S
Molecular Weight:498.565
Hs Code.:

Synonyms:1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

There total 6 articles about 1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: C₃₀H₃₀N₆O₃S

: 218297-83-7
1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Guidance literature:: With trifluoroacetic acid; Heating / reflux;

Reference yield:

: 218301-12-3
5-methyl-2-(2-oxy-isoquinolin-7-yl)-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

: 218297-83-7
1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Guidance literature:: 5-methyl-2-(2-oxy-isoquinolin-7-yl)-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide; With pyridine; p-toluenesulfonyl chloride; at 20 ℃;

With ethanolamine; at 20 ℃;

With trifluoroacetic acid; for 4h; Heating;
DOI:10.1021/jm020578e

Reference yield:

: 23707-37-1
7-aminoisoquinoline

: 218297-83-7
1-(1'-amino-isoquinol-7'-yl)-3-methyl-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: aq. NaNO₂; aq. HCl / 0.5 h / 0 °C

1.2: SnCl₂; aq. HCl / 1 h / 0 °C

2.1: AcOH / 14 h / Heating

3.1: Me₃Al / CH₂Cl₂; hexane / 0.5 h / 20 °C

3.2: CH₂Cl₂; hexane / 14 h / 40 °C

4.1: m-chloroperbenzoic acid / acetone / 20 °C

5.1: pyridine; TsCl / 20 °C

5.2: ethanolamine / 20 °C

5.3: 1.60 g / TFA / 4 h / Heating

With pyridine; hydrogenchloride; trimethylaluminum; acetic acid; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; sodium nitrite; In hexane; dichloromethane; acetone;
DOI:10.1021/jm020578e