N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide

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Chemical Name:N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide
CAS No.:218301-11-2
Molecular Formula:C₃₀H₂₉N₅O₃S
Molecular Weight:539.658
Hs Code.:

Synonyms:N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide

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Technology Process of N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide

There total 3 articles about N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 218301-10-1
ethyl 1-(isoquinolyn-7'-yl)-3-methyl-5-pyrazole carboxylate

: 218301-11-2
N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: With trimethylaluminum; In dichloromethane; at 20 - 40 ℃; for 15h;

Reference yield:

: 23707-37-1
7-aminoisoquinoline

: 218301-11-2
N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaNO₂; aq. HCl / 0.5 h / 0 °C

1.2: SnCl₂; aq. HCl / 1 h / 0 °C

2.1: AcOH / 14 h / Heating

3.1: Me₃Al / CH₂Cl₂; hexane / 0.5 h / 20 °C

3.2: CH₂Cl₂; hexane / 14 h / 40 °C

With hydrogenchloride; trimethylaluminum; acetic acid; sodium nitrite; In hexane; dichloromethane;
DOI:10.1021/jm020578e

Reference yield:

: isoquinolin-7-yl-hydrazine; compound with GENERIC INORGANIC NEUTRAL COMPONENT

: 218301-11-2
N-{2'-[(tert-butylamino)sulfonyl]-1,1'-biphenyl-4-yl}-1-(7-isoquinolyl)-3-methyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcOH / 14 h / Heating

2.1: Me₃Al / CH₂Cl₂; hexane / 0.5 h / 20 °C

2.2: CH₂Cl₂; hexane / 14 h / 40 °C

With trimethylaluminum; acetic acid; In hexane; dichloromethane;
DOI:10.1021/jm020578e