4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline

Base Information

• Chemical Name: 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline
• CAS No.: 1147207-18-8
• Molecular Formula: C₁₃H₁₅ClF₃N₃O₂
• Molecular Weight: 337.729
• Mol file: 1147207-18-8.mol

Synonyms:4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline

Chemical Property of 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline

There total 2 articles about 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

3-(trifluoromethyl)piperidine (768-31-0,749208-62-6) + 4,5-dichloro-N-methyl-2-nitrobenzenamine (107342-18-7) → 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline (1147207-18-8)

Guidance literature:

3-(trifluoromethyl)piperidine; 4,5-dichloro-N-methyl-2-nitrobenzenamine; With potassium carbonate; In N,N-dimethyl-formamide; at 70 - 80 ℃;

With potassium carbonate; In DnfMF (N,N-dimethylformamide); at 20 - 100 ℃; for 26h;

Reference yield:

1,2-dichloro-4-fluoro-5-nitrobenzene (2339-78-8) → 4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline (1147207-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; toluene

2.1: potassium carbonate / N,N-dimethyl-formamide / 70 - 80 °C

2.2: 26 h / 20 - 100 °C

With potassium carbonate; In N,N-dimethyl-formamide; toluene;

Reference yield: 90.0%

4-chloro-N-methyl-2-nitro-5-(3-(trifluoromethyl)piperidin-1-yl)aniline (1147207-18-8) → 5-chloro-2-methylamino-4-(3-(trifluoromethyl)piperidin-1-yl)aniline (1380920-94-4)

Guidance literature:

With hydrogen; platinum on activated charcoal; In tetrahydrofuran; methanol; at 35 ℃; for 4h; under 2400.24 Torr;

upstream raw materials:

1,2-dichloro-4-fluoro-5-nitrobenzene

3-(trifluoromethyl)piperidine

4,5-dichloro-N-methyl-2-nitrobenzenamine

Downstream raw materials:

5-chloro-2-methylamino-4-(3-(trifluoromethyl)piperidin-1-yl)aniline

tert-butyl N-{4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl) piperidin-1-yl)]-1H-benzo[d]imidazol-2-ylaminolbenzyl}-carbamate

4-chloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzo[d]imidazol-2-ylamino]benzylamine