9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine

Base Information

• Chemical Name: 9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine
• CAS No.: 100827-87-0
• Molecular Formula: C₃₃H₃₅N₇O₄
• Molecular Weight: 593.685

Synonyms:9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine

Chemical Property of 9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine

Chemical Property:

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Technology Process of 9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine

There total 5 articles about 9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-hydroxy-2-phenyl-ethyl)-isoindole-1,3-dione (35645-98-8) → 9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine (100827-87-0)

Guidance literature:

Multi-step reaction with 4 steps

1: HCl / 1,2-dichloro-ethane / 3 h

2: 24 percent / Et₃N / dimethylformamide / 55 h

3: 2.) aq. methylamine / 1) 90 deg C, 18 h; 2) 90 deg C, 6.5 h

4: 1.) ethyl chloroformate, Et₃N, 2.) Et₃N / 1) THF, 0 - 5 deg C, 10 min; 2) CHCl₃, 1.5 h, room temperature

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; methylamine; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1002/jps.2600741211

Reference yield:

1-phenyl-2-phthalimidoethoxymethyl chloride (100827-92-7) → 9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine (100827-87-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 24 percent / Et₃N / dimethylformamide / 55 h

2: 2.) aq. methylamine / 1) 90 deg C, 18 h; 2) 90 deg C, 6.5 h

3: 1.) ethyl chloroformate, Et₃N, 2.) Et₃N / 1) THF, 0 - 5 deg C, 10 min; 2) CHCl₃, 1.5 h, room temperature

With chloroformic acid ethyl ester; triethylamine; methylamine; In N,N-dimethyl-formamide;

DOI:10.1002/jps.2600741211

Reference yield:

2-Amino-1-phenylethanol (7568-93-6,1936-63-6) → 9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine (100827-87-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 81 percent / acetic acid / 4 h / Heating

2: HCl / 1,2-dichloro-ethane / 3 h

3: 24 percent / Et₃N / dimethylformamide / 55 h

4: 2.) aq. methylamine / 1) 90 deg C, 18 h; 2) 90 deg C, 6.5 h

5: 1.) ethyl chloroformate, Et₃N, 2.) Et₃N / 1) THF, 0 - 5 deg C, 10 min; 2) CHCl₃, 1.5 h, room temperature

With hydrogenchloride; chloroformic acid ethyl ester; triethylamine; methylamine; In acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1002/jps.2600741211

upstream raw materials:

Z-DL-Phe-OH

2-(2-hydroxy-2-phenyl-ethyl)-isoindole-1,3-dione

1-phenyl-2-phthalimidoethoxymethyl chloride

6-chloro-9-(1-phenyl-2-phthalimidoethoxymethyl)purine

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