35645-98-8

Basic information

• Product Name: 2-(2-hydroxy-2-phenyl-ethyl)-isoindole-1,3-dione
• Synonyms: 2-(2-hydroxy-2-phenyl-ethyl)-isoindole-1,3-dione
• CAS NO: 35645-98-8
• Molecular Weight: 267.284
• Mol File: 35645-98-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-(2-hydroxy-2-phenyl-ethyl)-isoindole-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-hydroxy-2-phenyl-ethyl)-isoindole-1,3-dione(35645-98-8)
• EPA Substance Registry System: 2-(2-hydroxy-2-phenyl-ethyl)-isoindole-1,3-dione(35645-98-8)

Safety Data

• Hazardous Substances Data: 35645-98-8(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 7568-93-6 2-Amino-1-phenylethanol 
• 70-11-1 α-bromoacetophenone 
• 1074-82-4 potassium phtalimide 
• 98-88-4 benzoyl chloride 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 1032-67-3 N-benzoylmethylphthalimide 
• 18042-62-1 N-<(Trimethylsilyl)methyl>phthalimide 
• 100-52-7 benzaldehyde 
• 17564-64-6 N-(chloromethyl)phthalimide 
• 101284-31-5 N-(β-hydroxy-phenethyl)-phthalamic acid 
• 96-09-3 styrene oxide 
• 136918-14-4 phthalimide 

Downstream Products

• 102028-68-2 N-(2-acetoxy-2-phenyl)ethylphthalimide 
• 101727-91-7 N-(4-nitro-β-nitryloxy-phenethyl)-phthalimide 
• 7568-93-6 2-Amino-1-phenylethanol 
• 100827-92-7 1-phenyl-2-phthalimidoethoxymethyl chloride 
• 23092-87-7 2-[(E)-2-phenylvinyl]-1H-isoindole-1,3(2H)-dione 
• 100827-87-0 9-(2-N-carbobenzoxyphenylalanylamido-1-phenylethoxymethyl)-6-dimethylaminopurine 
• 100827-95-0 6-chloro-9-(1-phenyl-2-phthalimidoethoxymethyl)purine 
• 475473-46-2 3-hydroxy-2-(2-hydroxy-2-phenyl-ethyl)-2,3-dihydro-isoindol-1-one 
• 550-44-7 N-methylphthalimide 
• 1032-67-3 N-benzoylmethylphthalimide 
• 100-52-7 benzaldehyde 

Relevant articles and documents

FUSED [1,2,4]THIADIAZINE DERIVATIVES WHICH ACT AS KAT INHIBITORS OF THE MYST FAMILY

A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1 and MOF.

On the configurational stability of chiral heteroatom-substituted [D 1]Methylpalladium complexes as intermediates of stille and suzuki-miyaura cross-coupling reactions

Enantiomerically pure (S)-tributylstannyl[D1]methanol and (R)- and (S)-tributylstannyl[D1]methyl benzoates were Stille-coupled with bromobenzene and benzoyl chloride in 1,4-dioxane and toluene using [(Ph 3P)4Pd] or [(Ph3P)2PdCl2] either alone or in combination with CuCN as cocatalyst at temperatures up to 80 °C. The products were found to be enantiomerically pure. (R)- and (S)-N-(tributylstannyl[D1]methyl)phthalimides gave enantiomerically pure products with benzoyl chloride, but with bromobenzene protected phenyl[D1]methylamines gave products of only 52-69 % ee depending on the solvent used. Tributyl(thio[D1]methyl)stannanes could not be Stille-coupled with benzoyl chloride or with bromobenzene. Similarly, dimethyl phenyl[D1]methylboronate underwent a Suzuki-Miyaura coupling with bromobenzene to give phenyl[D1]methylsilane with 99 % ee. All couplings followed a retentive course and, except in one case, the intermediate [XCHDPdLn] complexes were found to be microscopically configurationally stable. Stille coupling of enantiomerically pure tributylstannyl[D1]methanol, its benzoate, and the N-(tributylstannyl[D1]methyl)phthalimide with bromobenzene and benzoyl chloride furnished products containing a chiral XCHD group. Overall net retention of configuration was found in all cases.

An expedient chemo-enzymatic method for the synthesis of optically active masked 1,2-amino alcohols

The expedient synthesis of enantiopure masked 1,2-amino alcohols (ee >99%) including their alkyl substituted analogues has been achieved by the regioselective ring opening of epoxides using phthalimide, followed by highly efficient kinetic resolution under mild and environmentally friendly conditions. The addition of co-solvents during kinetic resolution significantly improved the enantioselectivity with reduction in time.