Technology Process of cis-3,3-dichloro-1-isopropyl-2,4-diphenylazetidine
There total 5 articles about cis-3,3-dichloro-1-isopropyl-2,4-diphenylazetidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
dimethyl sulfoxide;
at 90 ℃;
for 48h;
DOI:10.1021/jo970342w
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) lithium diisopropylamide / 1.) THF, hexane, 0 -> -15 deg C, 2.) THF, hexane, -15 -> 0 deg C, 1 h
2: 77 percent / pyridine / 15 h / Ambient temperature
3: 88 percent / NaCNBH3, acetic acid / methanol / 24 h / Ambient temperature
4: 63 percent / potassium carbonate / dimethylsulfoxide / 48 h / 90 °C
With
pyridine; sodium cyanoborohydride; potassium carbonate; acetic acid; lithium diisopropyl amide;
In
methanol; dimethyl sulfoxide;
DOI:10.1021/jo970342w
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) lithium diisopropylamide / 1.) THF, hexane, 0 -> -15 deg C, 2.) THF, hexane, -15 -> 0 deg C, 1 h
2: 77 percent / pyridine / 15 h / Ambient temperature
3: 88 percent / NaCNBH3, acetic acid / methanol / 24 h / Ambient temperature
4: 63 percent / potassium carbonate / dimethylsulfoxide / 48 h / 90 °C
With
pyridine; sodium cyanoborohydride; potassium carbonate; acetic acid; lithium diisopropyl amide;
In
methanol; dimethyl sulfoxide;
DOI:10.1021/jo970342w
