diethyl 2-acetyl-5,10-dideazafolate

Base Information

• Chemical Name: diethyl 2-acetyl-5,10-dideazafolate
• CAS No.: 95674-75-2
• Molecular Formula: C₂₇H₃₁N₅O₇
• Molecular Weight: 537.572
• Mol file: 95674-75-2.mol

Synonyms:diethyl 2-acetyl-5,10-dideazafolate

Chemical Property of diethyl 2-acetyl-5,10-dideazafolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-acetyl-5,10-dideazafolate

There total 6 articles about diethyl 2-acetyl-5,10-dideazafolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate (95674-74-1) → diethyl 2-acetyl-5,10-dideazafolate (95674-75-2) + diethyl 2-acetyl-5,10-dideaza-5,6,7,8-tetrahydrofolate (95674-76-3)

Guidance literature:

With hydrogen; trifluoroacetic acid; palladium on activated charcoal; for 14h; under 2844.3 Torr; Ambient temperature;

DOI:10.1021/jm00145a012

Reference yield:

2,4-diamino-6-(4-carboxystyryl)-5-deazapteridine (95674-66-1) → diethyl 2-acetyl-5,10-dideazafolate (95674-75-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 88 percent / 1N NaOH / 3 h / Heating

2: 84 percent / 4-(dimethylamino)pyridine / 3 h / 120 °C

3: 77 percent / 1N NaOH / H₂O

4: 1.) N-methylpyrrolidone, N-methylmorpholine, phenyl N-phenylphosphoramidochloridate / 1.) 0 deg C, 30 min, 2.) RT, overnight

5: 56 percent / TFA, H₂ / 5percent Pd/C / 14 h / 2844.3 Torr / Ambient temperature

With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; dmap; sodium hydroxide; hydrogen; Phenyl N-phenylphosphoramidochloridate; trifluoroacetic acid; palladium on activated charcoal; In water;

DOI:10.1021/jm00145a012

Reference yield:

2,4-diamino-6-<4-(tert-butoxycarbonyl)styryl>-5-deazapteridine (95674-65-0) → diethyl 2-acetyl-5,10-dideazafolate (95674-75-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 92 percent / HCl / nitromethane / 1 h / 0 °C

2: 88 percent / 1N NaOH / 3 h / Heating

3: 84 percent / 4-(dimethylamino)pyridine / 3 h / 120 °C

4: 77 percent / 1N NaOH / H₂O

5: 1.) N-methylpyrrolidone, N-methylmorpholine, phenyl N-phenylphosphoramidochloridate / 1.) 0 deg C, 30 min, 2.) RT, overnight

6: 56 percent / TFA, H₂ / 5percent Pd/C / 14 h / 2844.3 Torr / Ambient temperature

With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; hydrogenchloride; dmap; sodium hydroxide; hydrogen; Phenyl N-phenylphosphoramidochloridate; trifluoroacetic acid; palladium on activated charcoal; In nitromethane; water;

DOI:10.1021/jm00145a012

upstream raw materials:

diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate

4-<2-(2-amino-1,4-dihydro-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoic acid

2,4-diamino-6-(4-carboxystyryl)-5-deazapteridine

2-acetamide-6-(4-carboxystyryl)-5-deaza-4(3H)-pteridinone

Downstream raw materials:

5,10-dideazafolic acid