diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate

Base Information

• Chemical Name: diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate
• CAS No.: 95674-74-1
• Molecular Formula: C₂₇H₂₉N₅O₇
• Molecular Weight: 535.557
• Mol file: 95674-74-1.mol

Synonyms:diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate

Chemical Property of diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate

There total 5 articles about diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-<2-(2-amino-1,4-dihydro-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoic acid (95674-71-8) → diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate (95674-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / 4-(dimethylamino)pyridine / 3 h / 120 °C

2: 77 percent / 1N NaOH / H₂O

3: 1.) N-methylpyrrolidone, N-methylmorpholine, phenyl N-phenylphosphoramidochloridate / 1.) 0 deg C, 30 min, 2.) RT, overnight

With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; dmap; sodium hydroxide; Phenyl N-phenylphosphoramidochloridate; In water;

DOI:10.1021/jm00145a012

Reference yield:

2,4-diamino-6-(4-carboxystyryl)-5-deazapteridine (95674-66-1) → diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate (95674-74-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / 1N NaOH / 3 h / Heating

2: 84 percent / 4-(dimethylamino)pyridine / 3 h / 120 °C

3: 77 percent / 1N NaOH / H₂O

4: 1.) N-methylpyrrolidone, N-methylmorpholine, phenyl N-phenylphosphoramidochloridate / 1.) 0 deg C, 30 min, 2.) RT, overnight

With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; dmap; sodium hydroxide; Phenyl N-phenylphosphoramidochloridate; In water;

DOI:10.1021/jm00145a012

Reference yield:

2,4-diamino-6-<4-(tert-butoxycarbonyl)styryl>-5-deazapteridine (95674-65-0) → diethyl 2-acetyl-5,10-dideaza-9,10-didehydrofolate (95674-74-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 92 percent / HCl / nitromethane / 1 h / 0 °C

2: 88 percent / 1N NaOH / 3 h / Heating

3: 84 percent / 4-(dimethylamino)pyridine / 3 h / 120 °C

4: 77 percent / 1N NaOH / H₂O

5: 1.) N-methylpyrrolidone, N-methylmorpholine, phenyl N-phenylphosphoramidochloridate / 1.) 0 deg C, 30 min, 2.) RT, overnight

With 4-methyl-morpholine; 1-methyl-pyrrolidin-2-one; hydrogenchloride; dmap; sodium hydroxide; Phenyl N-phenylphosphoramidochloridate; In nitromethane; water;

DOI:10.1021/jm00145a012

upstream raw materials:

diethyl-L-glutamate hydrochloride

2-acetamide-6-(4-carboxystyryl)-5-deaza-4(3H)-pteridinone

4-<2-(2-amino-1,4-dihydro-4-oxopyrido<2,3-d>pyrimidin-6-yl)ethenyl>benzoic acid

2,4-diamino-6-(4-carboxystyryl)-5-deazapteridine

Downstream raw materials:

5,10-dideaza-9,10-didehydrofolic acid

diethyl 2-acetyl-5,10-dideazafolate

diethyl 2-acetyl-5,10-dideaza-5,6,7,8-tetrahydrofolate

N-(4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]-pyrimidin-6-yl)ethyl]benzoyl)-L-glutamic acid