Technology Process of methyl 3-amino-5-chloro-2-ethylbenzoate
There total 5 articles about methyl 3-amino-5-chloro-2-ethylbenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 5-chloro-2-ethyl-3-nitrobenzoate;
With
ammonium chloride;
In
methanol; water;
at 70 ℃;
With
water; iron;
In
methanol;
at 70 ℃;
for 3.5h;
Product distribution / selectivity;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / methanol / 1 h / 20 °C
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C
3.1: nitric acid; sulfuric acid / methanol / 1.25 h / -5 - 0 °C / Cooling with ethanol-ice
3.2: 6 h / 0 °C / Inert atmosphere; Reflux
4.1: ammonium chloride; iron / water; methanol / 2.5 h / 20 - 70 °C
With
sulfuric acid; hydrogen; nitric acid; iron; potassium carbonate; ammonium chloride;
palladium 10% on activated carbon;
In
methanol; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; triphenylphosphine; copper(l) iodide / palladium diacetate / 20 h / 20 - 50 °C / Inert atmosphere
2.1: potassium carbonate / methanol / 1 h / 20 °C
3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C
4.1: nitric acid; sulfuric acid / methanol / 1.25 h / -5 - 0 °C / Cooling with ethanol-ice
4.2: 6 h / 0 °C / Inert atmosphere; Reflux
5.1: ammonium chloride; iron / water; methanol / 2.5 h / 20 - 70 °C
With
copper(l) iodide; sulfuric acid; hydrogen; nitric acid; iron; potassium carbonate; ammonium chloride; triethylamine; triphenylphosphine;
palladium 10% on activated carbon; palladium diacetate;
In
methanol; water; ethyl acetate;
