942273-38-3

Upstream product

• 289039-82-3 methyl 5-chloro-2-iodo-benzoate 
• 1066-54-2 trimethylsilylacetylene 
• 27007-53-0 methyl-2-bromo-5-chlorobenzoate 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 494210-98-9 methyl 5-chloro-2-[((trifluoromethyl)sulfonyl)oxy]benzoate 
• 13421-00-6 5-chloro-2-iodo-benzoic acid 

Downstream Products

• 942273-26-9 methyl 5-chloro-2-ethynylbenzoate 
• 942273-28-1 C₂₄H₁₇Cl₂NO₄S 
• 942273-39-4 C₂₄H₂₁Cl₂NO₄S 
• 1310378-92-7 methyl 5-chloro-2-ethylbenzoate 
• 1403258-46-7 methyl 5-chloro-2-ethyl-3-nitrobenzoate 
• 1403258-47-8 methyl 3-amino-5-chloro-2-ethylbenzoate 
• 1403258-50-3 methyl 5-chloro-2-ethyl-3-[(oxan-4-yl)amino]benzoate 
• 1403258-51-4 5-chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoic acid 
• 1403258-55-8 5-chloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzamide 
• 1403256-11-0 N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4-ethyl-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide 
• 1403591-18-3 5-chloro-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2-ethyl-3-[methyl(oxan-4-yl)amino]benzamide 
• 1403596-43-9 methyl 5-chloro-2-ethyl-3-[methyl(oxan-4-yl)amino]benzoate 
• 1403596-44-0 5-chloro-2-ethyl-3-[methyl(oxan-4-yl)amino]benzoic acid 
• 1403258-53-6 methyl 5-chloro-2-ethyl-3-[ethyl(oxan-4-yl)amino]benzoate 

Relevant academic research and scientific papers

Hydroiodination-Triggered Cascade Reaction with I2/PPh3/H2O: Metal-Free Access to 3-Substituted Phthalides from 2-Alkynylbenzoates

Phthalide is an important scaffold found in several biologically active compounds. Therefore, effective methods for the synthesis of phthalides are strongly desired. Herein, we describe the metal-free synthesis of 3-substituted phthalides by the reductive hydroiodination of 2-alkynylbenzoates through an I2/PPh3/H2O-triggered cascade reaction. A variety of 3-substituted phthalides were synthesized in excellent yields by a one-pot reaction involving four processes: desilylation, hydroiodination, cyclization, and reduction.

Condensed-cyclic compound and organic light emitting diode comprising the same

Disclosed are a condensed-ring compound and an organic light-emitting device comprising the same. The condensed-ring compound is represented by chemical formula 1. The organic light-emitting device comprising the condensed-ring compound can have low driving voltage, high efficiency, high brightness, and long durability.COPYRIGHT KIPO 2016

Intramolecular C-H activation through gold(I)-catalyzed reaction of iodoalkynes

The cycloisomerization reaction of 1-(iodoethynyl)-2-(1-methoxyalkyl)arenes and related 2-alkyl-substituted derivatives gives the corresponding 3-iodo-1-substituted-1H-indene under the catalytic influence of IPrAuNTf2 [IPr = 1,3-bis(2,6-diisopropyl)phenylimidazol-2-ylidene; NTf2 = bis(trifluoromethanesulfonyl)imidate]. The reaction takes place in 1,2-dichloroethane at 80°C, and the addition of ttbp (2,4,6-tritert-butylpyrimidine) is beneficial to accomplish this new transformation in high yield. The overall reaction implies initial assembly of an intermediate gold vinylidene upon alkyne activation by gold(I) and a 1,2-iodine-shift. Deuterium labeling and crossover experiments, the magnitude of the recorded kinetic primary isotopic effect, and the results obtained from the reaction of selected stereochemical probes strongly provide support for concerted insertion of the benzylic C-H bond into gold vinylidene as the step responsible for the formation of the new carbon-carbon bond.

SUBSTITUTED BENZENE COMPOUNDS

The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Aryl- or Heteroaryl-Substituted Benzene Compounds

The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

Cycloisomerization of aromatic homo and bis-homopropargylic alcohols via catalytic ru vinylidenes: Formation of benzofurans and isochromenes

Ru-catalyzed cycloisomerizations of aromatic homo- and bis-homopropargylic alcohols effectively afford benzofurans and isochromenes. These processes proved to be chemo- and regioselective (5-, and 6-endo cyclizations) derived from key Ru vinylidene intermediates. The presence of an amine/ammonium base-acid pair is crucial for the catalytic cycle.

Preparation of novel anthranilic acids as antibacterial agents. Extensive evaluation of alternative amide bioisosteres connecting the A- and the B-rings

In the past few years, a significant effort has been devoted by Pharmacia toward the discovery of novel antibiotics. We have recently described the identification of an anthranilic acid lead 1 and the optimization resulting in the advanced lead 2. In this report, we describe the preparation of several selected amide bioisosteres connecting the A- and the B-rings. The E-alkene provided a rigid analog with equal potency to the corresponding amide. This indicates that the amide is not a recognition element rather acts as an appropriate spatial linker of the two important aryl A and B rings. The work here clearly demonstrates that the amide linker can be replaced with several functionalities without significant deterioration in the MIC activity.