5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol

Base Information

Chemical Name:5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol
CAS No.:862374-54-7
Molecular Formula:C₂₇H₂₁F₃N₂O₄
Molecular Weight:494.47
Hs Code.:

Synonyms:5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol

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Chemical Property of 5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol

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Technology Process of 5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol

There total 8 articles about 5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 448957-17-3
N-(4-(3-(allyloxy)-4-fluorophenoxy)benzyl)-N-(2,4-difluorobenzyl)-N-(2-methyl-3-nitrophenyl)amine

: 862374-54-7
5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm050205o

Reference yield:

: 448957-15-1
3-(allyloxy)-4-fluorophenol

: 862374-54-7
5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 73 percent / K₂CO₃ / dimethylformamide / 14 h / 100 °C

2.1: AcOH / CH₂Cl₂ / 4 h / 20 °C

2.2: 88 percent / Na(OAc)3BH / CH₂Cl₂ / 12 h / 20 °C

3.1: 100 percent / diisopropylethylamine / dimethylformamide / 18 h / 100 °C

4.1: 92 percent / Pd(PPh₃)4; phenylsilane / CH₂Cl₂ / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050205o

Reference yield:

: 862374-44-5
4-(3-(allyloxy)-4-fluorophenoxy)benzaldehyde

: 862374-54-7
5-(4-(((2,4-difluorobenzyl)(2-methyl-3-nitrophenyl)amino)methyl)phenoxy)-2-fluorophenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: AcOH / CH₂Cl₂ / 4 h / 20 °C

1.2: 88 percent / Na(OAc)3BH / CH₂Cl₂ / 12 h / 20 °C

2.1: 100 percent / diisopropylethylamine / dimethylformamide / 18 h / 100 °C

3.1: 92 percent / Pd(PPh₃)4; phenylsilane / CH₂Cl₂ / 2 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenylsilane; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050205o